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姓 名： | 何化 |
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职 称： | 副教授 | ||||
导师类别： | 硕士研究生导师 | ||||
系 室： | 生物与能源化工系 | ||||
研究领域： | 生物分析化学 | ||||
电子邮箱： | huahe@upc.edu.cn | ||||
联系电话： | 0532-86981135 | ||||
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◎教育背景 | |||||
1998-2002， 湖南师范大学化学化工学院，理学学士 2002-2005， 湖南师范大学化学化工学院，理学硕士 2005-2008， 上海交通大学化学化工学院，工学博士 2014-2015， 美国斯坦福大学化学系，国家公派访问学者 | |||||
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◎工作经历 | |||||
2008-2010，中国石油大学（华东）化学化工学院，讲师 2010-至今，中国石油大学（华东）化学化工学院，副教授 | |||||
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◎研究方向 | |||||
[1] 单分子/单颗粒/单细胞荧光成像分析 [2] 功能纳米探针的设计、合成及生物医学应用 [3] 表面增强荧光成像用于高灵敏生物检测和体外诊断 | |||||
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◎科研项目 | |||||
[1] 国家自然科学基金面上项目（21874154），《细胞膜上G蛋白偶联受体聚集与分布的荧光闪烁碳点超分辨成像》，主持 [2] 国家自然科学基金青年项目（20905078），《基于RGD配体设计的CdTe量子点靶向探针的直接合成及其应用》，主持 [3] 山东省自然基金面上项目（ZR2014BM028），《荧光闪烁量子点用于细胞中趋化因子受体CCR3的三维超分辨定位与分布研究》，主持 [4] 山东省自然基金青年项目（ZR2009BQ001），《基于RGD肽的量子点靶向探针制备新方法研究及应用》，主持 [5] 中央高校基本科研业务基金（18CX02126A），《荧光碳纳米材料的制备及其在生物成像中的应用》，主持 [6]中央高校基本科研业务基金（12CX04053A），《单个量子点的光学行为、调控及其应用研究》，主持 | |||||
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◎代表性论文及专利 | |||||
1.论文 以第一作者或通讯作者在Science Advances, Angew. Chem. Int. Ed., Nano Lett., Anal. Chem., ACS sensor等权威刊物发表论文30余篇，总引1300多次，单篇最高被引300多次。 [1] Qian Wang, Qian Zhang, Hua He,* Zhenzhen Feng, Jian Mao, Xiang Hu, Xiaoyun Wei, Si-min Bi, Guangyong Qin, Xiaojuan Wang, Baosheng Ge, Daoyong Yu, Hao Ren and Fang Huang* Carbon Dot Blinking Fingerprint Uncovers Native Membrane Receptor Organizations via Deep Learning. Analytical Chemistry 2022, 94(9), February 21. [2] X. Mu, J. Wang, Hua He (co-first), Qifeng Li, Bing Yang, Junhui Wang, Haile Liu, Yalong Gao, Lufei Ouyang, Si Sun, Qinjuan Ren, Xinjian Shi, Wenting Hao, Qiaoman Fei, Jiang Yang, Lulin Li, Ryan Vest, Tony Wyss-Coray, Jian Luo, and Xiao-Dong Zhang*. An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury. Science Advances 2021, 7(46), eabk1210 [3] Hua He,* Xiaoliang Chen, Zhenzhen Feng, Lihua Liu, Qian Wang, and Simin Bi. Nanoscopic Imaging of Nucleolar Stress Enabled by Protein-Mimicking Carbon Dots. Nano Letters 2021, 21(13), 5689–5696 [4] Naseer Ullah Khan, Muhammad Zahir, Xukun Liu, Jing Lin, Qihong Zheng, Huajie Zhang, Samiullah Malik, Hua He ,* and Liming Shen.* Ultra-sensitive detection of exosome using biofunctionalized gold nanorods on silver-island film. Nano Letters 2021, 21(13), 5532–5539. [5] Qian wang, Hua He,* Qian Zhang, Zhenzhen Feng, Jiqiang Li, Xiaoliang Chen, Lihua Liu, Xiaojuan Wang, Baosheng Ge, Daoyong Yu, Hao Ren and Fang Huang* Deep-Learning-Assisted Single-Molecule Tracking on a Live Cell Membrane. Analytical Chemistry 2021, 93(25), 8810–8816. [6] Hua He, Lihua Liu, Xiaoliang Chen, Qian wang, Xiaojuan Wang, Werner M. Nau, and Fang Huang. Carbon Dot Blinking Enables Accurate Molecular Counting at Nanoscale Resolution. Analytical Chemistry 2021, 93(8), 3968–3975. [7] Qian wang, Zhenzhen Feng, Hua He,* Jiqiang Li, Xiaoliang Chen, Lihua Liu, Xiaojuan Wang, Baosheng Ge, Daoyong Yu, Hao Ren and Fang Huang*. Nonblinking Carbon Dots for Imaging and Tracking Receptors on Live Cell membrane. Chemical Communications 2021, 57(45), 5554-5557. [8] Hua He,* Di Liu, Zhenzhen Feng, Aijun Guo, Lihua Liu, and Xiaoliang Chen. Antifade Carbon Dots on Plasmonic Substrate for Enhanced Protein Detection in Immunotherapy. ACS Sensors 2020, 5(12), 4027-4034. [9] Hua He, Xinjian Shi, Junying Wang, Xiaojuan Wang, Qian Wang, Daoyong Yu, Baosheng Ge, Xiaodong Zhang and Fang Huang. Reactive Oxygen Species-Induced Aggregation of Nanozymes for Neuron Injury. ACS Applied Materials & Interfaces 2020, 12(1), 209-216. [10] Lufei Ouyang, Xiaoyu Mu, Junying Wang, Qifeng Li, Yalong Gao, Haile Liu, Si Sun, Qinjuan Ren, Ruijuan Yan, Jingya Wang, Qiang Liu, Yuanming Sun, Changlong Liu, Hua He,* Wei Long and Xiaodong Zhang*. Carbon dot targeting to nitrogen signaling molecules for inhibiting neuronal death. Journal of Materials Chemistry B 2020, 8(11), 2321-2330. [11] Xiaoyu Mu, Hua He (co-first), Junying Wang, Wei Long, Qifeng Li, Haile Liu, Yalong Gao, Lufei Ouyang, Qinjuan Ren, Si Sun, Jingya Wang, Jiang Yang, Qiang Liu, Yuanming Sun, Changlong Liu, XiaoDong Zhang, Wenping Hu. Carbogenic Nanozyme with Ultrahigh RNS Selectivity for Traumatic Brain Injury. Nano Letters 2019, 19(7), 4527-4534. [12] Naseer Ullah Khan, Hua He*, Xiaojuan Wang, Baosheng Ge, Qian Wang, Xu Liu, Jun Lao, Yanan Wang, Jiqiang Li, Zhencai Wang, Shitan Zhou, and Fang Huang*. A Two-Color Fluorescence Enhanced Dot-Blot Assay for Revealing Co-operative Expression of Chemokine Receptors in Cells. Chemical Communications 2018, 54, 778-781. [13] Hua He, Shan Li, Xinjian Shi, Xiaojuan Wang, Xu Liu, Qian Wang, Aijun Guo, Baosheng Ge, Naseer Ullah Khan, and Fang Huang*, Quantitative Nanoscopy of Small Blinking Graphene Nanocarriers in Drug Delivery. Bioconjugate Chemistry 2018, 29 (11), 3658–3666. [14] Naseer Ullah Khan, Zhenzhen Feng, Hua He*, Qian Wang, Xu Liu, Shan Li, Xinjian Shi, Xiaojuan Wang, Baosheng Ge and Fang Huang*, A Facile Plasmonic Silver Needle for Fluorescence-Enhanced Detection of Tumor Markers. Analytica Chimica Acta 2018, 1040, 120-127. [15] Hua He, Xu Liu, Shan Li, Xiaojuan Wang, Qian Wang, Jiqiang Li, Junying Wang, Hao Ren, Baosheng Ge, Shengjie Wang, Xiaodong Zhang, Fang Huang, High-Density Super-Resolution Localization Imaging with Blinking Carbon Dots. Analytical Chemistry 2017, 89 (21), 11831-11838. [16] Jun Lao, Hua He (co-first), Xiaojuan Wang, Zhencai Wang, Yanzhuo Song, Bin Yang, Naseer Ullahkhan, Baosheng Ge*, Fang Huang*. Single-Molecule Imaging Demonstrates Ligand Regulation of Oligomeric Status of CXCR4 in Living Cells. The Journal of Physical Chemistry B 2017, 121 (7), 1466-1474. [17] Hua He, Zhencai Wang, Tiantian Cheng, Xu Liu, Xiaojuan Wang, Junying Wang, Hao Ren, Yawei Sun, Yanzhuo Song, Jiang Yang, Yongqing Xia, Shengjie Wang, Xiaodong Zhang*, and Fang Huang*. Visible and Near-Infrared Dual-Emission Carbogenic Small Molecular Complex with High RNA Selectivity and Renal Clearance for Nucleolus and Tumor Imaging. ACS Applied Materials & Interfaces 2016, 8 (42), 28529-28537. [18] Hua He, Xiaojuan Wang, Tiantian Cheng, Yongqing Xia, Jun Lao, Baosheng Ge, Hao Ren, Naseer Ullah Khan, Fang Huang*. An Ultra-High Fluorescence Enhancement and High Throughput Assay for Revealing Expression and Internalization of Chemokine Receptor CXCR4. Chemistry-A European Journal 2016, 22, 5863-5867. [19] Hua He*, Xiaojuan Wang, Zhenzhen Feng, Tiantian Cheng, Xing Sun, Yawei Sun, Yongqing Xia, Shengjie Wang, Junying Wang, Xiaodong Zhang*. Rapid microwave-assisted synthesis of ultra-bright fluorescent carbon dots for live cell staining, cell-specific targeting and in vivo imaging. Journal of Materials Chemistry B 2015, 3, 4786-4789. [20] Hua He, Xing Sun, Xiaojuan Wang, Yawei, Sun, Hai Xu*, Jian R. Lu*. Cyclic Arginyl-Glycyl-Aspartic Acid (RGD) Peptide-Induced Synthesis of Uniform and Stable One-Dimensional CdTe Nanostructures in Aqueous Solution. RSC Advances 2014, 4, 11794-11797. [21] Hua He, Min Feng, Jing Hu, Cuixia Chen, Jiqian Wang, Xiaojuan Wang, Hai Xu*, Jian R. Lu*. Designed Short RGD Peptides for One-Pot Aqueous Synthesis of Integrin-binding CdTe and CdZnTe Quantum Dots. ACS Applied Materials & Interfaces 2012, 4, 6362-6370. [22] Hua He, Chao Xie, Jicun Ren*. Non-Bleaching Fluorescence of Gold Nanoparticles and Its Applications in Cancer Cell Imaging. Analytical Chemistry 2008, 80(15): 5951-5957. [23] Hua He, Jicun Ren*. A Novel Evanescent Wave Scattering Imaging Method for Single Gold Particle Tracking in Solution and on Cell Membrane. Talanta 2008, 77(1):166-171. [24] Hua He, Huifeng Qian, Chaoqing Dong, Kanglin Wang, Jicun Ren*. Single nonblinking CdTe quantum dots synthesized in aqueous thiopropionic acid. Angewandte Chemie International Edition 2006, 45(45): 7588-7591. [25] Hua He, Qingji Xie, Shouzhuo Yao*. An electrochemical quartz crystal impedance study on anti-human immunoglobulin G immobilization in the polymer grown during dopamine oxidation at an Au electrode. Journal of Colloid and Interface Science 2005, 289, 446-454. | |||||
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◎代表性著作 | |||||
[1] Hua He, Xiaojuan Wang, Fang Huang. Analysis and Applications of Single Molecule Fluorescence in Live Cell Membranes, in: Membrane Biophysics: New Insights and Methods, Springer 2018, pp 147-173. | |||||
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◎获奖情况及荣誉称号 | |||||
[1] 2018年青岛市自然科学奖三等奖 [2] 2008年上海交大优秀毕业生” [3] 2008年香港求是研究生奖学金 [4] 2007年国家优秀奖学金 [5] 2005年湖南师范大学优秀毕业生（研究生） [6] 2002年湖南师范大学优秀本科毕业生 | |||||
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◎执教课程 | |||||
本科生：双语课程《生物物理化学》、《生物物理化学》、《材料与健康》、《材料与环境》》 研究生：留学生课程《仪器分析技术及应用》、《生物材料》、《生物仪器分析技术》 | |||||
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◎招收及指导研究生情况 | |||||
1.指导研究生情况 指导博士研究生3名，学术研究生2名，专业硕士研究生13名。毕业研究生9名，其中1名到深圳大学生命与海洋科学学院工作（副研究员），1名到扬州大学攻读博士学位，3名到药明生物和药明康德工作，2名到齐鲁制药工作，1名到烟台绿叶制药工作、1名到青岛卫生健康局工作。 2.招生专业及要求 生物化工、生物工程、生物与医药 | |||||
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◎学术兼职 | |||||
[1] Frontiers in Chemistry (中科院二区)编委 [2] 天津大学医工结合基金评审专家 | |||||
